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98% Hydroxypropyl beta Cyclodextrin Powder

Specifications: 98%

Detection method: HPLC


Molecular formula: C54H102O39

Molecular weight: 1375.36

Shipping speed:1-3 days

Inventory:In stock

Certificates:HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA

    What is Hydroxypropyl Beta Cyclodextrin?

    Hydroxypropyl-β-cyclodextrin (HP-β-CD) is one of the derivatives of β-cyclodextrin (β-CD). Natural cyclodextrin and its derivatives are cyclic oligosaccharides obtained by enzymatic cyclization of starch. Hydroxypropyl-β-cyclodextrin is the substitution product of hydroxypropyl ether of β-cyclodextrin under alkaline conditions. Substituting hydroxypropyl groups for the hydroxyl groups in cyclodextrin makes hydroxypropyl-β-cyclodextrin highly water-soluble (≥ 600mg/mL).

    Hydroxypropyl-β-cyclodextrin is composed of 7 α-glucopyranose monomers, each monomer is replaced by 0 to 3 hydroxypropyl ethers. The chemical structure is shown in the figure. Its unique ring structure gives the molecule a hydrophilic outer surface and a hydrophobic inner cavity. The degree of substitution (DS) of the entire molecule is 7 molar degrees of substitution (the average number of substituted hydroxyl groups per monomer is called the molar degree of substitution). Each of the seven monomers may have different numbers of hydroxyl groups substituted, resulting in a variety of combinations of different degrees of substitution for each molecule.
    HP-β-CD not only has an excellent enveloping effect on many compounds like β-CD, improving the solubility and stability of the encapsulated substances, but it also has high water solubility and improves the stability of the encapsulated drugs in the body. Advantages of release rate and bioavailability. In addition, HP-β-CD is a pharmaceutical excipient with the most extensive safety data collected and no adverse side effects. HP-β-CD can also be used as a protein protectant and stabilizer.
    What Is Hydroxypropyl Beta Cyclodextrinfzu

    Features and safety features

    1. HP-beta-CD has high water solubility at room temperature, generally exceeding 50%, so it cannot crystallize in alcohol aqueous solution.
    2. HP-beta-CD and β-CD have different selectivities for enveloped substances, and the proportion of molecules enveloped by certain substances may change.
    3. HP-beta-CD is basically not catabolized or accumulated in the human body. Most of the HP-beta-CD taken orally is excreted with the stool. When administered parenterally, almost all HP-beta-CD is excreted with the urine.
    4. HP-beta-CD can promote the rapid release of enveloped substances in the body.
    5. HP-beta-CD has lower surface activity and hemolytic activity than β-CD or other derivatives (such as methylated-beta-CD), making it safer to use.

    Application direction

    The introduction of hydroxypropyl group breaks the intramolecular cyclic hydrogen bond of β-cyclodextrin and overcomes the main shortcoming of poor water solubility of β-cyclodextrin while maintaining the cyclodextrin cavity. It is one of the most extensively researched and widely used cyclodextrin derivatives. Mainly used in food, medicine and cosmetics industries.
    1. In the field of food and spices, it can improve the stability and long-term effect of nutritional molecules, mask or correct the bad smell and taste of food nutritional molecules, and improve the production process and product quality. This product has good solubility in water. It can be miscible with water in any proportion with a substitution degree of 4 or above. It can also be dissolved in 50% ethanol and methanol.
    2. Used as stabilizers, emulsifiers, deodorants, etc. in cosmetic raw materials, which can reduce the stimulation of skin and mucous membrane tissues by organic molecules in cosmetics, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity.
    3. In the pharmaceutical industry, it is an ideal solubilizer and pharmaceutical excipient for injections due to its low relative surface activity and hemolytic activity and no irritation to muscles. It can improve the water solubility of poorly soluble drugs, increase drug stability, improve drug bioavailability, increase the efficacy of the drug or reduce the dosage, adjust or control the release rate of the drug, and reduce the toxic and side effects of the drug. It can be used as a carrier for oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, lipophilic targeted drugs, and can also be used as a protectant and stabilizer for proteins.
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