What is DL mandelic acid used for?
What is DL-Mandelic Acid?
Mandelic acid is a lipophilic acid with antibacterial ability, high affinity to the skin, strong permeability, and is milder than glycolic acid. It was first extracted from peach leaves and willow leaves,from the same source as salicylic acid.Its chemical structure is similar to antibiotics, so it can inhibit the growth of a variety of bacteria. The good lipophilicity and antibacterial properties of mandelic acid make it effective in improving acne, photoaging and post-inflammatory pigmentation. Salicylic acid-mandelic acid has been used clinically for skin peeling related treatments. In addition, mandelic acid also has a certain whitening effect. Its chemical properties include white orthorhombic flake crystals. It will change color and decompose when exposed to light. Easily soluble in ether, isopropyl alcohol, soluble in ethanol and water. The acidity coefficient (pKa) of mandelic acid is 3.85 (at 25°C), solubility in water is 139 g/L, storage conditions are recommended to be stored in an environment below +30°C.
Compared with the common fruit acid-glycolic acid, mandelic acid has certain antibacterial ability. It is milder than glycolic acid and can inhibit the growth of many bacteria due to its chemical structure similar to antibiotics.At the same time, compared with the common glycolic acid and lactic acid, its skin penetration speed will be slower, that is, Chemicalbook says that it is less irritating than glycolic acid. Its fat solubility increases, and its ability to penetrate the stratum corneum is improved. Like glycolic acid and lactic acid, mandelic acid also has a certain whitening effect.
What Are The Functions Of DL-Mandelic Acid?
As the first generation of fruit acid, mandelic acid (mandelic acid) shows extraordinary anti-acne ability. Other fruit acids are all water-soluble. When they encounter the skin, they are naturally easily blocked by oil, affecting their penetration ability. However, fat-soluble mandelic acid can penetrate deep into the sebaceous glands, reduce oil secretion, and regulate the source of acne, Propionibacterium acnes.
1.Exfoliant
Mandelic acid can accelerate cell renewal and act as a powerful exfoliant to remove dead skin cells. Compared with other exfoliants, mandelic acid has a larger molecular weight. It enters the skin slowly, so it is not too irritating to the skin, and its chemical properties also give it an advantage in abrasive physical exfoliants.
2.Control acne
Mandelic acid can dissolve the skin's old dead skin cells, promote skin metabolism, stimulate the regeneration of the basal skin, and has certain antibacterial properties, which can fight against Propionibacterium acnes (P.acnes) bacteria. At the same time, it regulates sebum secretion, thereby controlling the occurrence of acne.
3.Reduce pigmentation
Mandelic acid's properties of increasing cell renewal and exfoliation mean that melanin deposited in stratum corneum cells can be removed, brightening the skin. Therefore, mandelic acid can reduce excessive pigmentation (such as dark spots, melasma, and sunburn).
4.Unclog pores and help penetration
Unclog pores can solve many skin problems. Mandelic acid can penetrate pores and remove excess oil, dirt and dead skin cells. This helps control acne and promotes better penetration of other skin care products.
5.Control fine lines and wrinkles
Mandelic acid can increase collagen in the skin, helping to improve the elasticity of the skin and protect it from fine lines and wrinkles.
6.Reconstruct the skin barrier
Mandelic acid can repair the skin barrier and give the skin a youthful glow.
What Is The Application Of DL-Mandelic Acid?
Mandelic acid is a compound with multiple uses and a wide range of applications.
1.Application in skin care products
Mandelic acid is popular in beauty skincare. It has a rejuvenating effect and is suitable for sensitive skin. Mandelic acid is one of the cosmetic products that has caused a sensation. It has become a great alternative to the famous vitamin C and hyaluronic acid treatments.
Mandelic acid is mainly used as an antioxidant in skin care products. It can inhibit the production of free radicals, promote cell metabolism, and help improve skin dullness, spots and other problems. It can reduce the production of melanin and make the skin brighter and more lustrous.
2.Special reagent in organic synthesis
Mandelic acid is used as a special reagent in organic synthesis to determine the content of zirconium. It is a white rhombic flaky crystal with a melting point of 119°C and is easily soluble in hot water, ether, isopropanol and ethanol.
3.In the medical field
Mandelic acid has antibacterial and anti-inflammatory effects and is often used as an ingredient in topical drugs, such as anti-acne and anti-skin infection agents. It has an inhibitory effect on the activity of Staphylococcus aureus sortase A and has the potential to become an inhibitor of Staphylococcus aureus infection. Its application in the medical field also includes the treatment of mild to moderate facial acne with fire needles combined with mandelic acid, which shows good efficacy.