Do you know what phloretin is?

Do you know what phloretin is?

Phloretin, whose chemical name is 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone, is a natural plant component belonging to flavonoids. It is mainly distributed in apple branches and leaves, apple fruits/skin , the rhizome/bark of apple trees, lychee peel, Tibetan medicine "Russian leaves" and other plants. Phloretin has a variety of biological activities, including pharmacological effects such as antioxidant, anti-inflammatory, immunosuppressive, and promotion of bone formation. It also has cosmetic effects such as whitening and removing acne.

Phloretin is widely distributed in nature and is mainly found in the root bark and peel of certain plants. For example, the peel and root bark of juicy fruits such as apples and pears are rich in phloretin. However, it is worth noting that naturally occurring phloretin is present in very small amounts in plants and is usually present in the form of its glycoside derivative, phlorizin. The phloridzin absorbed by the human body can generate phloretin after the glycoside group is removed from the gastric mucosa, and then enters the circulation system to play its role.

Phloretin has many significant effects. It has a strong antioxidant function and can scavenge free radicals in the skin. Its antioxidant concentration on oil is between (10~30)×10-6. It can prevent sugar components from entering epidermal cells, thereby inhibiting excessive secretion of cutaneous glands and treating acne with strong secretion. It can also inhibit the activity of melanocytes and have a lightening effect on various skin problems.

What are the effects of phloretin?

Phloretin is a natural compound with a variety of biological activities. It belongs to the dihydrochalcone plant polyphenols and can be extracted from apple and grapefruit peels. Its main role in nature is to protect plants from UV damage, while in human skin care, phloretin has significant antioxidant, anti-inflammatory and photoprotective effects.

Phloretin has strong antioxidant properties and can eliminate the increase of free radicals in the skin and damage to cells and DNA caused by ultraviolet rays. This action helps prevent premature aging of the skin and reduces the occurrence of wrinkles and other age-related skin problems.

Phloretin can inhibit the excessive secretion of sebaceous glands, which is particularly beneficial for the treatment of excessive secretion of acne. By reducing sebum production, phloretin can help keep skin fresh and healthy.

Phloretin can also inhibit the activity of melanocytes and have a lightening effect on various skin spots. When combined with other natural ingredients such as arbutin and kojic acid, phloretin can enhance the inhibitory effect on tyrosinase, thus improving the whitening effect of the product. The whitening mechanism of phloretin is mainly by inhibiting the activity of tyrosinase in the body, thereby reducing the production of melanin. Studies have found that phloretin has a better inhibitory effect on tyrosinase than common whitening agents (such as arbutin).

As a lipophilic compound, phloretin can change the membrane dipole potential of the phospholipid bilayer, affect the interface organization of the phospholipid bilayer and the penetration of water, thereby promoting the skin absorption of other ingredients.

What is the antioxidant mechanism of phloretin?

As a flavonoid, phloretin contains multiple phenolic hydroxyl groups in its structure. These phenolic hydroxyl groups enable phloretin to react with free radicals and thereby scavenge free radicals. Free radicals are harmful substances produced by oxidation reactions and are related to degenerative diseases in the human body. Phloretin helps reduce the damage caused by oxidative stress to the human body by scavenging free radicals.

The antioxidant concentration of phloretin on oil is between 10 and 30 ppm. Within this concentration range, the root bark

Vitamins can significantly exert antioxidant effects. Lipid peroxidation is a chain reaction process of oxidative degradation of unsaturated fatty acids, which produces a variety of free radicals and harmful products. Phloretin can inhibit the extended stage of lipid peroxidation and reduce the generation and accumulation of free radicals.

In vitro experiments show that phloretin has a strong ability to scavenge DPPH free radicals and ABTS free radicals. Its IC50 values ​​are 10 μmol/L and 4.54 μmol/L respectively. These data prove that phloretin has significant antioxidant effect.

How does phloretin remove free radicals?

As a natural antioxidant, phloretin can remove free radicals in the skin and protect the skin from oxidative damage. Its antioxidant function comes from the hydrogen or electron donating ability of its phenolic hydroxyl group.

Phloretin is mainly distributed in the peel and root bark of juicy fruits such as apples and pears. People take it into the body by eating these fruits or cosmetics containing phloretin. Phloretin can inhibit the excessive secretion of sebaceous glands and is used to treat acne with vigorous secretion. In addition, it can also inhibit the activity of melanocytes and has an effect on various skin spots. Phloretin has a strong antioxidant function and can remove free radicals in the skin. It can absorb 4 to 5 times its own weight of water and promote the absorption and utilization of other functional factors in the formula.

In summary, phloretin removes free radicals in the body through its antioxidant effect, thereby protecting cells from damage.

What can phloretin be used for?

1.Cosmetics

Phloretin is widely used in cosmetics because of its antioxidant, anti-inflammatory, sunscreen, transdermal absorption, whitening, moisturizing, antibacterial and anti-hair loss effects. It can be added to cosmetics such as facial masks, skin creams, lotions and essences to improve the whitening, moisturizing and antioxidant effects of the products. In addition, phloretin can inhibit the excessive secretion of sebaceous glands and is used to treat acne with strong secretion; it can inhibit the activity of melanocytes and has a lightening effect on various skin spots.

2.Food and health care products

Although the search results do not directly mention the application of phloretin in food and health care products, based on other relevant information, we can understand that phloretin has many important biological activities such as lowering blood sugar, improving memory, and anti-oxidation. Therefore, phloretin also has broad application prospects in the field of food and health care products.

3.Pharmaceutical field

In the pharmaceutical field, phloretin can be used as a raw material for drug development and used to prepare drugs for the treatment of skin cancer and other diseases. The main source of phloretin extraction is the peel and root bark of juicy fruits such as apples and pears.