DNA Sodium/PDRN/Salmon PDRN

What is PDRN?

What Are The Benefits?

• Skin Regeneration
  PDRN (Polydeoxyribonucleotide) is a hydrolyzed regenerative tissue that can rapidly induce tissue regeneration, promote cell regeneration, and accelerate wound healing. It activates the skin’s innate regenerative ability, replenishing the elastic fibers lost due to aging. When PDRN enters the body, it binds with cells to restore the internal environment of the skin to its optimal state, repairing skin damaged by physical, chemical, and UV stimuli.

• Strong Compatibility
  PDRN uses patented technology to evenly divide the DNA of salmon (extracted from salmon reproductive cells, which closely resemble human DNA structure) and refine it into polynucleotides. PDRN has a high similarity to human DNA, with a base similarity of up to 98%, giving it a strong ability to repair cell tissues. It improves the physiological conditions of damaged skin, restoring the internal environment and fundamentally solving skin problems. In other words, PDRN extracted from salmon cells does not cause immune reactions when applied to the human body, and its unique compatibility increases its practicality.

• Long-Lasting Anti-Aging
  The mechanism of PDRN involves the participation of adenosine A2A receptors. PDRN specifically activates the A2A adenosine receptor on the cell surface, promoting the release of cytokines, generating anti-inflammatory effects, and repairing damaged cells. This receptor activation leads to the proliferation of osteoblasts, fibroblasts, and adipocyte precursor cells. Additionally, VEGF (vascular endothelial growth factor) and angiopoietin are released, improving blood circulation and making the skin plumper, fuller, and more radiant, achieving a long-lasting anti-aging effect.

• Skin Barrier Repair
  PDRN promotes the secretion of VEGF, accelerating the migration, proliferation, and formation of blood vessels. It improves skin microcirculation, providing more oxygen and nutrients to skin cells, which accelerates skin tissue repair and regeneration. It enhances the skin’s moisture retention and resistance, helping to rebuild and repair the skin barrier. PDRN also promotes tissue repair, speeding up the regeneration and healing of damaged skin tissue, allowing sensitive skin to effectively resist external stimuli, increase skin thickness and elasticity, and improve skin sensitivity issues.

• Anti-Inflammatory
  Inflammation, often referred to as the "root of all diseases," can be chronic and persist in the body, damaging bodily functions and affecting quality of life. Chronic inflammation in the skin’s deeper layers can cause blood vessel dilation, resulting in redness, swelling, and pain. Numerous studies show that PDRN can significantly inhibit inflammatory responses, reducing redness, swelling, and pain in the skin. PDRN regulates the expression of inflammatory factors, suppressing excessive inflammation and promoting the production of anti-inflammatory factors while inhibiting pro-inflammatory factors. PDRN assists in the treatment of various inflammatory skin conditions, increases skin hydration, enhances skin thickness, and improves skin sensitivity. It is effective against neurogenic inflammation and rosacea.

• Melanin Inhibition
  PDRN can reduce melanin production in cells, lower the activity of tyrosinase, and inhibit the expression of related transcription factors and proteins. It has certain therapeutic effects on melasma and photoaging spots.

Test report

Applications 

Applications of PDRN with different molecular weights:
① 700 KDa and above are used for skin regeneration, joint cartilage regeneration and bone formation promotion;
② 350~500 KDa are used in pharmaceutical treatment to achieve tissue regeneration, corneal regeneration and treatment of musculoskeletal diseases;
③ 40~60 KDa are used in cosmetics and foods to achieve barrier repair, wrinkle improvement and skin beauty.
Summary: PDRN can generate nucleotides and nucleosides that accelerate DNA synthesis, improve fibroblast proliferation and growth ability, vascular endothelial growth factor expression, promote angiogenesis, improve microcirculation, and provide nutrition for skin tissue regeneration; inhibit the expression of inflammatory cytokines and apoptotic proteins, and exert a strong anti-inflammatory effect; in addition, PDRN can also protect tissue cells from UV-induced DNA damage.

Formulation of Capsaicin

Capusle Formulation

Tablet formulation