01
98% Pauka Genistein
He aha ka genistein?
He waiwai nui ko Sophora japonica i ka lāʻau lapaʻau. I nā makahiki i hala iho nei, ua ʻike ʻia he mau hana pharmacological like ʻole. No ka laʻana, no nā isoflavones ka genistein. He papa huahana kūlohelohe nā Isoflavones me nā hana physiological ikaika, me ka antioxidant, anti-hemolysis, antibacterial, a me ka pale ʻana i nā maʻi cardiovascular, ʻoiai no ka mea he like ka mamao o ko lākou ʻano molekala ma waena o nā hui me α-estradiol. Loa a pōkole, lilo ia i ʻano phytoestrogens.
ʻO Genistein, i ʻike ʻia hoʻi ʻo 5,7,4-trihydroxyisoflavone, genistein, genistein, etc., ua loaʻa nui ʻia mai nā soybeans, clover, kudzu root, sophora japonica, genistein (gorse) a me nā mea hana i lawe ʻia mai nā mea kanu leguminous e like me ke aʻa pīni ākea. ʻO Genistein, ka mea nui o nā isoflavones soy, he ʻano like me ka estrogen, no laila ua kapa ʻia ʻo "phytoestrogens". ʻOiai ʻo ka hemahema o ka estrogen kahi kumu nui o ka osteoporosis i nā wahine postmenopausal, ʻo genistein kekahi o nā wahi noiʻi o kēia manawa o nā lāʻau lapaʻau anti-osteoporosis botanical. Ua kuhikuhi nā "Latest Guidelines" o ka National Osteoporosis Foundation (NOF) he mea maikaʻi loa ka genistein i ke olakino iwi o nā wahine postmenopausal. ʻO ia wale nō ka mea hana mea kanu i manaʻo ʻia e ka FDA he palekana akā pono nō hoʻi i nā ʻikepili lapaʻau anti-osteoporosis hou aʻe. .
Ua hōʻike ʻia nā haʻawina he nui e hiki i ka genistein ke hōʻoluʻolu i ka mumū, hoʻololi i ka flora ʻōpū, a hoʻomaikaʻi i ka hana pale epithelial i loko o kekahi mau hiʻohiʻona holoholona o nā maʻi ʻōpū. Eia kekahi, ua ʻike ʻia ʻo genistein he hopena maikaʻi i nā maʻi e pili ana i ka makahiki e like me nā maʻi neurodegenerative a me nā maʻi cardiovascular, ka nalowale o ka iwi, a me ka ʻelemakule ʻana o ka ʻili, akā ʻo kona kuleana kikoʻī i ka homeostasis ʻōpū ʻelemakule e pono e wehewehe ʻia.
He aha nā pono
Anti-osteoporosis
Ma ke ʻano he "phytoestrogen", hiki i ka genistein ke hoʻoulu i ka hoʻonui ʻana, ka hoʻokaʻawale ʻana a me ka mineralization o nā hana hoʻokumu iwi o nā osteoblasts, a hiki nō hoʻi ke kāohi i ke kaʻina hana resorption iwi o nā osteoclasts. Loaʻa iā ia nā ʻano hana molekala anti-osteoporosis like ʻole.
ʻO ka hopena anti-osteoporosis o ka genistein e pili ana i nā hana e like me ka hoʻolaha ʻana i ka hoʻonui ʻana, ka hoʻokaʻawale ʻana a me ka hoʻokumu ʻana o ka iwi o nā osteoblasts a me ka pale ʻana i ka hoʻonui ʻana, ka hoʻokaʻawale ʻana a me ka resorption iwi o nā osteoclasts. Eia kekahi, ʻo genistein, ma ke ʻano he "phytoestrogen", e hoʻopaʻa i nā mea loaʻa estrogen (ER) i loko o ke kino e hana i kahi hopena hoʻoponopono. He hana hoʻoponopono estrogen koho kūpono ia o nā hui kūlohelohe.
Hiki i ka Genistein ke kāohi i ka hoʻoheheʻe ʻana o ka iwi osteoclastic ma o ke ala NF-κB. Eia kekahi, hiki i ka genistein ke hoʻoponopono i nā ala hōʻailona ion calcium intracellular a kāohi i nā kinase protein a me nā tyrosine kinases, a laila e hoʻoulu ai i ka apoptosis osteoclast a pēlā e kāohi ai i ka hoʻoheheʻe ʻana o ka iwi. Hiki ke hoʻemi ʻia ke kūkulu ʻia ʻana o Osteoclast ma ke kāohi ʻana i ka hana o ka DNA topoisomerase II.
Nā hopena like me ka estrogen o genistein
Ma ke ʻano he "phytoestrogen", he ʻano like ko genistein me nā estrogens endogenous (e like me 17β-Estradiol) a he mau hopena like me ka estrogen. Aia ʻelua ʻano o nā mea loaʻa estrogen i loko o ke kino kanaka, ʻo ia hoʻi ka estrogen receptor ɑ (REɑ) a me ka estrogen receptor β (REβ). Ma waho aʻe o ka ʻōnaehana hānau, aia ka ER ma nā osteoblasts, osteoclasts, a me nā cell stromal iwi. I waena o lākou, ua hōʻike nui ʻia ʻo ERɑ i nā osteocytes diaphyseal, a ua haʻahaʻa loa ka hōʻike ʻana o ERβ i nā osteocytes diaphyseal; Ua hōʻike nui ʻia ʻo ERβ i nā osteocytes iwi cancellous, a ua hōʻike pū ʻia i loko o ka nucleus a me ka cytoplasm o nā osteoclasts. ʻOi aku ka nui o ka pilina o genistein iā ERβ ma mua o ERα, akā ʻo kāna mea loaʻa nui no ka hoʻokō ʻana i ka hopena anti-osteoporosis ʻo ERα, no laila ʻo ERα ke ʻano nui o ka mea loaʻa no genistein e hoʻokō i ka hopena pale iwi. Eia kekahi, loaʻa i nā phytoestrogens kahi hopena hoʻoponopono bidirectional i ka wā e hui pū ʻia me ER i loko o ke kino, ʻo ia hoʻi, hōʻike lākou i nā hopena estrogen-like a anti-estrogen paha (e hoʻolaha ana i nā haʻahaʻa haʻahaʻa a kāohi i nā kiʻekiʻe kiʻekiʻe) ma lalo o nā kūlana like ʻole. He lāʻau lapaʻau kūpono ia no ka pani ʻana i ka estrogen.
ʻO Genistein a me nā maʻi cardiovascular
He kuleana koʻikoʻi ko Genistein i ka hōʻemi ʻana i ka nui o nā maʻi cardiovascular. Kiʻekiʻe ka cholesterol lipoprotein haʻahaʻa i loko o ke koko a maʻalahi hoʻi e oxidize, hiki ke hana i ka atherosclerosis. Hiki iā Genistein ke hōʻemi pono i ka cholesterol ma o nā hopena antioxidant, kāohi i ka oxidation o ka cholesterol lipoprotein haʻahaʻa (LDL), a hōʻemi i ka LDL i loko o ke koko. E mālama i ka pae ma kahi haʻahaʻa, hoʻomaikaʻi i ke kūlana peroxidation maʻamau i loko o ke kino i hoʻokumu ʻia e ka momona kiʻekiʻe, a hōʻoluʻolu i ka pōʻino peroxidative i ke kino. Hiki iā Genistein ke hoʻonui i nā mea loaʻa LDL a hoʻonui i ka hana receptor LDL, no laila e paipai ana i ka hoʻomaʻemaʻe cholesterol. Kāohi pū ʻo Genistein i ka hoʻonui ʻana o nā cell muscle laumania, angiogenesis a me ka hoʻopili ʻana o nā cell, no laila e hōʻemi ana i ka nui o nā maʻi cardiovascular.
ʻAno ʻike
