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98% Genistein Powder
He aha ka genistein?
He lāʻau lapaʻau kiʻekiʻe ko Sophora japonica. I nā makahiki i hala iho nei, ua ʻike ʻia he mau hana pharmacological like ʻole. No ka laʻana, no ka isoflavones ka genistein. ʻO ka Isoflavones kahi papa o nā huahana kūlohelohe me nā hana physiological ikaika, me ka antioxidant, anti-hemolysis, antibacterial, a me ka pale ʻana i ka maʻi cardiovascular, ʻoi aku hoʻi ma muli o ko lākou ʻano molekala he like ka mamao ma waena o ka α-estradiol. ʻO ka lōʻihi a me ka pōkole, lilo ia i ʻano phytoestrogens.
ʻO Genistein, ka mea i ʻike ʻia ʻo 5,7,4-trihydroxyisoflavone, genistein, genistein, a me nā mea ʻē aʻe, i loaʻa mai ka soybeans, clover, kudzu root, sophora japonica, genistein (gorse) a me nā mea hana i lawe ʻia mai nā mea kanu leguminous e like me ke aʻa pīni ākea. ʻO Genistein, ka mea nui o ka soy isoflavones, he ʻano like me ka estrogen, no laila ua kapa ʻia ʻo "phytoestrogens". ʻOiai ʻo ka nele o ka estrogen he kumu koʻikoʻi o ka osteoporosis i nā wahine postmenopausal, ʻo genistein kekahi o nā wahi noiʻi o kēia manawa o nā lāʻau anti-osteoporosis botanical. Ua kuhikuhi ʻia nā "Alakaʻi Hou" o ka National Osteoporosis Foundation (NOF) he mea maikaʻi loa ka genistein i ke olakino iwi o nā wahine postmenopausal. ʻO ia wale nō ka mea kanu mea kanu i manaʻo ʻia e ka FDA he palekana akā pono nō naʻe ka ʻikepili lapaʻau anti-osteoporosis. .
Ua hōʻike ʻia nā haʻawina he nui e hiki i ka genistein ke hoʻohaʻahaʻa i ka mumū, hoʻololi i ka pua ʻōpū, a hoʻomaikaʻi i ka hana pale epithelial i nā ʻano holoholona o nā maʻi ʻōpū. Eia kekahi, ʻike ʻia ka genistein i nā hopena maikaʻi i nā maʻi pili makahiki e like me nā maʻi neurodegenerative a me nā maʻi cardiovascular, ka nalowale o ka iwi, a me ka ʻelemakule o ka ʻili, akā ʻo kāna kuleana kūpono i ka homeostasis intestinal ʻelemakule e mau nei e elucidated.
He aha nā pōmaikaʻi
Anti-osteoporosis
Ma ke ʻano he "phytoestrogen", hiki i ka genistein ke hoʻoikaika i ka hoʻonui ʻana, ka ʻokoʻa a me ka mineralization o nā hana hoʻokumu iwi o nā osteoblasts, a hiki nō hoʻi ke kāohi i ke kaʻina hana hoʻihoʻi iwi o nā osteoclast. Loaʻa iā ia nā ʻano hana anti-osteoporosis molecular.
ʻO ka hopena anti-osteoporosis o genistein e pili ana i nā hana e like me ka hoʻouluʻana i ka hoʻonuiʻana, kaʻokoʻa a me ka hoʻokumuʻana i nā iwi o nā osteoblasts a me ka paleʻana i ka hoʻonuiʻana, kaʻokoʻa a me ka hoʻopiliʻana o ka iwi o nā osteoclast. Eia kekahi, ʻo genistein, ma ke ʻano he "phytoestrogen", hoʻopaʻa i nā mea hoʻokipa estrogen (ER) i loko o ke kino e hana i kahi hopena hoʻoponopono. ʻO ia kahi hana hoʻoponopono estrogen receptor koho maikaʻi loa. o na mea hoohui maoli.
Hiki iā Genistein ke kāohi i ka hoʻihoʻi ʻana o ka iwi osteoclastic ma o ke ala NF-κB. Eia hou, hiki i ka genistein ke hoʻopili i nā ala hōʻailona calcium ion intracellular a keʻakeʻa i ka protein kinases a me tyrosine kinases, a laila e hoʻoulu ai i ka osteoclast apoptosis a ma laila e pale ai i ka hoʻihoʻi ʻana o ka iwi. Hiki ke hōʻemi ʻia ka hoʻokumu ʻana o Osteoclast ma ke kāohi ʻana i ka hana o DNA topoisomerase II.
Nā hopena e like me Estrogen o genistein
Ma ke ʻano he "phytoestrogen", he ʻano like ko genistein me nā estrogens endogenous (e like me 17β-Estradiol) a loaʻa nā hopena like estrogen. Aia ʻelua ʻano o ka estrogen receptors i loko o ke kino o ke kanaka, ʻo ia ka estrogen receptor ɑ (REɑ) a me ka estrogen receptor β (REβ). Ma waho aʻe o ka ʻōnaehana hānau, aia ʻo ER ma nā osteoblasts, osteoclasts, a me nā pūnaewele stromal iwi. Ma waena o lākou, ua hōʻike nui ʻia ʻo ERɑ i nā osteocytes diaphyseal, a ua haʻahaʻa loa ka ERβ i nā osteocytes diaphyseal; Hōʻike nui ʻia ka ERβ i nā osteocytes iwi cancellous, a ua hōʻike pū ʻia i loko o ka nucleus a me ka cytoplasm o nā osteoclast. ʻOi aku ka nui o ka pilina o genistein i ka ERβ ma mua o ka ERα, akā ʻo kāna mea loaʻa nui no ka hoʻokō ʻana i ka hopena anti-osteoporosis ʻo ERα, no laila ʻo ERα ka subtype receptor nui no genistein e hoʻokō i ka hopena pale iwi. Eia kekahi, loaʻa i nā phytoestrogens ka hopena hoʻoponopono bidirectional i ka hui pū ʻana me ER i loko o ke kino, ʻo ia hoʻi, hōʻike lākou i nā hopena estrogen-like a i ʻole anti-estrogen (e hoʻolaha ana i nā haʻahaʻa haʻahaʻa a me ke kāohi ʻana i nā kiʻekiʻe kiʻekiʻe) ma lalo o nā kūlana like ʻole. He lāʻau hoʻololi kūpono o ka estrogen.
ʻO Genistein a me ka maʻi cardiovascular
He kuleana koʻikoʻi ka Genistein i ka hōʻemi ʻana i ka maʻi cardiovascular. ʻO ka cholesterol lipoprotein haʻahaʻa haʻahaʻa i loko o ke koko he kiʻekiʻe a maʻalahi hoʻi ka oxidized, hiki ke hoʻoulu i ke atherosclerosis. Hiki i ka Genistein ke hoʻemi pono i ka cholesterol ma o nā hopena antioxidant, keʻakeʻa i ka oxidation o ka lipoprotein cholesterol haʻahaʻa (LDL), a hoʻemi i ka LDL i loko o ke koko. E mālama i ka pae ma kahi haʻahaʻa, e hoʻomaikaʻi i ke kūlana peroxidation maʻamau i ke kino i hoʻokumu ʻia e ka momona kiʻekiʻe, a e hoʻēmi i ka pōʻino peroxidative i ke kino. Hiki i ka Genistein ke hoʻonui i ka LDL receptors a me ka hoʻonui ʻana i ka hana ʻana i ka LDL receptor, a laila e hoʻoikaika ana i ka hoʻomaʻemaʻe cholesterol. Hoʻopili pū ʻo Genistein i ka hoʻonui ʻana o nā ʻiʻo ʻiʻo maʻemaʻe, angiogenesis a me ka hoʻopili ʻana o nā cell, a laila e hōʻemi ana i ka maʻi o ka maʻi cardiovascular.
ʻAno ʻike
