DNA sodium/PDRN/Salmon PDRN

Kedu ihe bụ PDRN?

Kedu ihe bụ uru?

• Mmeghachi akpụkpọ ahụ
  PDRN (Polydeoxyribonucleotide) bụ anụ ahụ na-emezigharị nke hydrolyzed nke nwere ike ime ka anụ ahụ dị ngwa ngwa, kwalite mmepụta cell, na mee ka ọgwụgwọ ọnya dịkwuo ngwa. Ọ na-eme ka ikike imegharị akpụkpọ ahụ pụta ìhè, na-emejupụta eriri na-agbanwe agbanwe n'ihi ịka nká. Mgbe PDRN na-abanye n'ime ahụ, ọ na-ejikọta ya na mkpụrụ ndụ iji weghachi gburugburu ime akpụkpọ ahụ na ọnọdụ ya kacha mma, na-edozi akpụkpọ ahụ nke anụ ahụ, kemịkalụ, na ihe mkpali UV mebiri.

• Ndakọrịta siri ike
  PDRN na-eji teknụzụ nwere ikike kewaa DNA nke salmon (nke ewepụtara na mkpụrụ ndụ ọmụmụ salmon, nke yiri usoro DNA mmadụ) wee nụchaa ya ka ọ bụrụ polynucleotides. PDRN nwere myirịta dị elu na DNA mmadụ, yana myirịta ntọala ruru 98%, na-enye ya ike siri ike ịrụzi anụ ahụ sel. Ọ na-eme ka ọnọdụ physiological nke akpụkpọ ahụ mebiri emebi dịkwuo mma, na-eweghachi gburugburu ebe obibi ma na-edozi nsogbu akpụkpọ ahụ. N'ikwu ya n'ụzọ ọzọ, PDRN ewepụtara na mkpụrụ ndụ salmon anaghị akpata mmeghachi omume mgbochi mgbe etinyere ya na ahụ mmadụ, yana ndakọrịta pụrụ iche na-abawanye uru ya.

• Mgbochi ịka nká na-adịte aka
  Usoro nke PDRN gụnyere ntinye nke adenosine A2A nnabata. PDRN na-arụ ọrụ kpọmkwem A2A adenosine receptor na elu cell, na-akwalite ntọhapụ nke cytokines, na-emepụta mmetụta mgbochi mkpali, na ịrụzi mkpụrụ ndụ mebiri emebi. Nkwalite nnabata a na-eduga na mmụba nke osteoblasts, fibroblasts, na sel adipocyte precursor. Ọzọkwa, a na-ewepụta VEGF (vaskụla endothelial growth factor) na angiopoietin, na-eme ka mgbasa ọbara dịkwuo mma ma na-eme ka akpụkpọ ahụ dịkwuo mma, na-egbuke egbuke, na-egbuke egbuke, na-enweta mmetụta mgbochi ịka nká na-adịte aka.

• Mmezi ihe mgbochi akpụkpọ ahụ
  PDRN na-akwalite nzuzo nke VEGF, na-eme ka ọpụpụ, mmụba, na nhazi nke arịa ọbara. Ọ na-eme ka microcirculation akpụkpọ ahụ dịkwuo mma, na-enyekwu oxygen na nri na-edozi ahụ na sel anụ ahụ, nke na-eme ka nrụzi anụ ahụ dịkwuo elu na ịmaliteghachi. Ọ na-eme ka njigide mmiri na nguzogide anụ ahụ dịkwuo elu, na-enyere aka wughachi na imezi ihe mgbochi akpụkpọ ahụ. PDRN na-akwalite nrụzi anụ ahụ, na-eme ka ọ dị ọhụrụ na ọgwụgwọ anụ ahụ mebiri emebi, na-ekwe ka akpụkpọ ahụ dị nro na-eguzogide ihe mkpali mpụga nke ọma, na-amụba ọkpụkpụ anụ ahụ na nrịda, ma melite nsogbu anụ ahụ.

• Mgbochi mgbu
  Ọfụfụ, nke a na-akpọkarị "mgbọrọgwụ nke ọrịa niile," nwere ike ịdị ogologo oge ma nọgide na-adị n'ime ahụ, na-emebi ọrụ ahụ ma na-emetụta àgwà ndụ. Ọrịa na-adịghị ala ala n'ígwé dị omimi nke akpụkpọ ahụ nwere ike ime ka arịa ọbara gbasaa, na-ebute ọbara ọbara, ọzịza, na mgbu. Ọtụtụ ọmụmụ na-egosi na PDRN nwere ike igbochi nzaghachi mkpali, ibelata ọbara ọbara, ọzịza, na mgbu na akpụkpọ ahụ. PDRN na-achịkwa okwu nke ihe ndị na-egbuke egbuke, na-egbochi oke ọkụ ma na-akwalite mmepụta nke ihe ndị na-eme ihe na-eme ka ọ ghara ịdị na-egbochi ihe ndị na-emepụta ihe. PDRN na-enyere aka n'ịgwọ ọnọdụ akpụkpọ anụ dị iche iche na-afụ ụfụ, na-abawanye hydration akpụkpọ ahụ, na-eme ka ọkpụkpụ akpụkpọ ahụ dịkwuo mma, na-eme ka anụ ahụ dịkwuo mma. Ọ dị irè megide mbufụt neurogenic na rosacea.

• Mgbochi Melanin
  PDRN nwere ike ibelata mmepụta melanin n'ime sel, belata ọrụ nke tyrosinase, ma gbochie nkwupụta nke ihe odide ederede na protein ndị metụtara ya. Ọ nwere mmetụta ọgwụgwọ ụfọdụ na melasma na ntụpọ foto.

Nyochaa akụkọ

Ngwa

Ngwa nke PDRN nwere nha molekụla dị iche iche:
① 700 KDa na n'elu ka a na-eji maka imeghari akpụkpọ ahụ, nkwonkwo nkwonkwo cartilage na nkwalite ọkpụkpụ ọkpụkpụ;
② 350 ~ 500 KDa na-eji ọgwụgwọ ọgwụ eme ihe iji nwetaghachi anụ ahụ, mmeghari nke corneal na ọgwụgwọ nke ọrịa musculoskeletal;
③ 40 ~ 60 KDa na-eji ihe ịchọ mma na ihe oriri iji nweta nrụzi mgbochi, nkwalite wrinkle na ịma mma akpụkpọ ahụ.
Nchịkọta: PDRN nwere ike ịmepụta nucleotides na nucleosides nke na-eme ka njikọ DNA dịkwuo elu, na-eme ka mmụba nke fibroblast na ike ibu, vascular endothelial growth factor expression, na-akwalite angiogenesis, meziwanye microcirculation, na-enye ihe oriri na-edozi ahụ maka mmepụta anụ ahụ; na-egbochi okwu nke cytokines na-egbuke egbuke na protein apoptotic, ma na-eme ka ọ bụrụ ihe mgbochi siri ike; na mgbakwunye, PDRN nwekwara ike chebe mkpụrụ ndụ anụ ahụ site na mmebi DNA nke UV kpatara.

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