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Ifu ya Genistein ya 98%
Genistein ni iki?
Sophora japonica ifite agaciro gakomeye mu buvuzi. Mu myaka ya vuba aha, byagaragaye ko ifite ibikorwa bitandukanye byo mu buvuzi. Urugero, genistein iri muri isoflavones. Isoflavones ni ubwoko bw'ibicuruzwa karemano bifite ibikorwa bikomeye mu mubiri, birimo antioxidant, anti-hemolysis, antibacterial, no gukumira indwara z'umutima n'imitsi, cyane cyane ko imiterere yabyo ifite intera isa n'iya α-estradiol hagati y'amatsinda. Iba ndende kandi ngufi, iba ubwoko bwa phytoestrogens.
Genistein, izwi kandi nka 5,7,4-trihydroxyisoflavone, genistein, genistein, nibindi, ikomoka ahanini muri soya, clover, umuzi wa kudzu, sophora japonica, genistein (gorse) n'ibintu bikora bikomoka ku bimera by'ibinyamisogwe nk'umuzi w'ibishyimbo bigari. Genistein, igice cy'ingenzi cya isoflavones ya soya, ifite imiterere isa na estrogen, bityo yitwa "phytoestrogens". Kubera ko kubura estrogen ari impamvu ikomeye itera osteoporosis ku bagore bamaze gucura, genistein ni imwe mu miti y'ibimera ikoreshwa mu kurwanya osteoporosis. "Amabwiriza aheruka" y'Ikigo cy'Igihugu gishinzwe kurwanya osteoporosis (NOF) yagaragaje ko genistein ari ingirakamaro cyane ku buzima bw'amagufwa y'abagore bamaze gucura. Ni cyo kintu cyonyine FDA ifata nk'ikintu gitekanye ariko gikeneye amakuru menshi ajyanye no kurwanya osteoporosis.
Ubushakashatsi bwinshi bwagaragaje ko genistein ishobora kugabanya ububyimbirwe, igahindura imboga zo mu mara, kandi ikanoza imikorere y’ingufu mu ndwara nyinshi zo mu mara zo mu nyamaswa. Byongeye kandi, genistein izwiho kugira ingaruka nziza ku ndwara ziterwa no gusaza nka indwara z’ubwonko n’iz’umutima n’imitsi, gutakaza amagufwa, no gusaza uruhu, ariko uruhare rwayo mu gusaza kw’amara ntiruramenyekana neza.
Ni izihe nyungu
Kurwanya indwara yo gucika intege kw'amagufwa (osteoporosis)
Nk'umuti wa "phytoestrogen", genistein ishobora guteza imbere ukwiyongera, gutandukanya no gushyira mu gaciro imikorere y'amagufwa ya osteoblasts, kandi ishobora no kubuza uburyo amagufwa ya osteoclasts asubiramo. Ifite uburyo butandukanye bwo kurwanya osteoporosis.
Ingaruka za genistein zo kurwanya osteoporosis zikubiyemo uburyo nko guteza imbere ikwirakwira ry’uturemangingo tw’amagufwa, gutandukanya no kurema amagufwa no kubuza ikwirakwira ry’uturemangingo tw’amagufwa, gutandukanya no kongera gukurura amagufwa. Byongeye kandi, genistein, nka "phytoestrogen", ifatana na estrogen receptors (ER) mu mubiri kugira ngo ikore ingaruka zo kugenzura. Ni igikorwa cyiza cyo guhitamo estrogen receptors zigenga ibintu karemano.
Genistein ishobora gukumira kongera gusongera kw'amagufwa binyuze mu nzira ya NF-κB. Byongeye kandi, genistein ishobora kuyobora inzira zo gutanga ibimenyetso bya calcium ion mu ngirabuzima fatizo no gukumira protein kinases na tyrosine kinases, bityo bigatera apoptosis ya osteoclast bityo bikabuza kongera gusongera kw'amagufwa. Ikorwa rya osteoclast rishobora kandi kugabanuka no kubuza imikorere ya ADN topoisomerase II.
Ingaruka za genistein nk'iza estrogen
Nk'uko ari "phytoestrogen", genistein ifite imiterere isa na estrogens zo mu mubiri w'umuntu (nka 17β-Estradiol) kandi ifite ingaruka nk'iza estrogen. Hari ubwoko bubiri bwa estrogen receptors mu mubiri w'umuntu, ari bwo estrogen receptor ɑ (REɑ) na estrogen receptor β (REβ). Uretse uburyo bwo kubyara, ER iboneka ku ma osteoblasts, osteoclasts, na cells za mu magufwa. Muri zo, ERɑ igaragara cyane muri diaphyseal osteocytes, naho ERβ ikaba nke cyane muri diaphyseal osteocytes; ERβ igaragara cyane muri cancellous bone osteocytes, kandi igaragara no muri nucleus na cytoplasm ya osteoclasts. Imigenderanire ya genistein na ERβ iruta iyo kuri ERα, ariko receptor yayo nyamukuru yo kurwanya osteoporosis ni ERα, bityo ERα niyo receptor nyamukuru kugira ngo genistein ikore neza mu kurinda amagufwa. Byongeye kandi, phytoestrogens zigira ingaruka zo kugenzura impande ebyiri iyo zihujwe na ER mu mubiri, ni ukuvuga ko zigaragaza ingaruka zimeze nka estrogen cyangwa anti-estrogen (zituma umuntu agira ingano nke kandi zikagabanya ingano ye) mu bihe bitandukanye. Ni umuti mwiza wo gusimbura estrogen.
Genistein n'indwara z'umutima n'imitsi
Genistein igira uruhare runini mu kugabanya indwara z’umutima n’imitsi. Kolesteroli igabanya ubucucike mu maraso ni nyinshi kandi irahinduka mu buryo bworoshye, ibi bikaba byatera indwara z’imitsi. Genistein ishobora kugabanya neza kolesteroli binyuze mu ngaruka za antioxydants, ikabuza kolesteroli igabanya ubucucike mu maraso, kandi ikagabanya LDL. Igumane urugero ruri ku rugero ruto, ikongera ubushobozi bwo kugabanya ubucucike mu mubiri buterwa n’ibinure byinshi, kandi igagabanya kwangirika kwa peroxidative mu mubiri. Genistein ishobora kongera ubushobozi bwa LDL kandi ikongera imikorere ya LDL, bityo ikagabanya cholesterol. Genistein kandi ibuza ko imitsi yoroshye ikwirakwira, angiogenesis no gufatana kw’uturemangingo, bityo ikagabanya umubare w’indwara z’umutima n’imitsi.
Uburyo bwo gutahura
