Kurwanya Gusaza Byiza NMN Beta-Nicotinamide Mononucleotide Ifu ya NMN

NMN, izina ryuzuye: β-nicotinamide mononucleotide, ifite pH agaciro ka 3.0-4.0. Nibisanzwe bioaktike nucleotide ibaho mubinyabuzima bitandukanye kandi ni ibikoresho byo kwisiga. Igomba gukama ku bushyuhe bwicyumba kandi ikarindwa ububiko bwa Optical, hamwe nubuzima bwamezi 24, formulaire yimiti ni C11H15N2O8P, ikaba ari intera yingenzi hagati ya synthesis ya Coenzyme I-NAD +.

NMN ni ikintu kiranga umubiri w'umuntu kandi gikungahaye ku mbuto n'imboga zimwe. Kubera ko nikotinamide ari vitamine b3, NMN iri mu cyiciro cya vitamine B. Ifite uruhare runini mubikorwa byinshi bya biohimiki yumubiri wumuntu kandi bifitanye isano rya bugufi nubudahangarwa na metabolism.

NMN (nicotinamide mononucleotide) ni ikintu kibanziriza NAD +, cofactor ya proteine ​​ndende mu mubiri w'umuntu. Imikorere yacyo nayo igaragazwa cyane na NAD +. NAD + ni coenzyme y'ingirakamaro kuri poroteyine amagana ya enzyme mu mubiri w'umuntu, harimo na poroteyine yo kubaho igihe kirekire. Ibigize, bigenga ibikorwa byubuzima amagana mumubiri wumuntu.

1. Ifasha gutinda gusaza

NAD + (Coenzyme I) ikomeza itumanaho ryimiti hagati ya nucleus na mitochondria. Niba iri tumanaho rigabanutse, bizatera kugabanuka kwa mito-iyambere. Kugabanuka kwa mitochondriya nimpamvu ikomeye yo gusaza kwa selile. NAD + (Coenzyme I) irashobora kugumana imvugo isanzwe ya gen no gukomeza selile. Imikorere yigihe cyose itinda inzira yingirabuzimafatizo zihinduka ingirabuzimafatizo.

2. Ifasha kwirinda hejuru ya diyabete eshatu

Urufunguzo rwo kugabanya isukari mu maraso ni insuline. Niba uturemangingo twa pancreatic islet twangiritse tugatera indwara ya insuline, bizatera byoroshye diyabete. NMN irashobora gukangura ibikorwa bya insuline no gushimangira kubora ibinure na polysaccharide, bityo NMN irashobora kugabanya ibyago bya diyabete.

3. Ifasha kwirinda indwara z'umutima n'imitsi n'ubwonko

NMN ikora cyane cyane: kongera lipoprotein nyinshi cyane, kugabanya lipoproteine ​​nkeya, kuba oxyde, kugabanya igisubizo cya macrophage, kugabanya imiterere ya plaque ya aterosklerotike, kongera ituze rya plaque ya aterosklerotike, no kugabanya guturika kwa plaque. , kunoza umuvuduko wamaraso nubundi buryo bwavuzwe haruguru kugirango wirinde kandi uvure indwara zifata umutima.

4. Ifasha kongera ubudahangarwa

NMN irashobora guteza imbere umusaruro wa antibodies ikoresheje selile spleen selile, ikongera imikorere yumubiri wa immun T, igatera umusaruro wa immunoglobuline mumubiri, kandi ikagira ingaruka zikomeye zo kugenzura indwara.

5. Ifasha kwirinda umuvuduko ukabije wamaraso

NMN ahanini ibuza kandi igahindura aterosklerose yuzuza NAD, bigatuma ingirabuzimafatizo zifasha buhoro buhoro kugarura ingirabuzimafatizo zoroheje z'imitsi y'amaraso, bityo bikagarura ubwonko bw'amaraso. Muri icyo gihe, irinda kongera gukora trombus binyuze mu ngaruka zo kurwanya inflammatory, hanyuma igafungura ingwate zahagaritswe ikaguka. ubwinshi bwamaraso, bityo buhoro buhoro kandi bikomeza kugabanya umuvuduko wamaraso.

6. Komeza ubushobozi bwo kuvugurura capillary

Ingirabuzimafatizo zirekura ibintu bikura mugihe cyimyitozo ngororamubiri, kandi capillary epidermal selile yakira ibintu bikura kugirango byihute gukura. Iyi nzira iterwa na proteine ​​ndende Sirtuin1 yakozwe na NAD + (Coenzyme I). Umuntu ukuze, NAD + (Coenzyme I), hamwe na siporo Ingaruka zo gukuza imitsi bizaba bibi.

7. Inzoga metabolism

Inzoga metabolism igabanyijemo intambwe ebyiri. Ubwa mbere, ihindurwamo ubumara bwa acetaldehyde, hanyuma ikangirika ikabamo aside aside itagira ingaruka. Buri ntambwe igomba gushingira kuri catalizike ya coenzyme I.

8. Ifasha kurinda amaso

Ubushakashatsi bwerekanye ko NMN inyura mu buryo bworoshye inzitizi y’amaraso n’ubwonko bwa selile, ishobora gukumira neza okiside ya retine, kandi ikagira uruhare mu kurinda sisitemu yo hagati y’imitsi, cyane cyane ubwonko, bityo ikavura neza ibikomere byo mu mitsi yo hagati nko gukomeretsa umugongo, syndrome ya Parkinson, syndrome ya Alzheimer, n’ibindi byangiritse. By'umwihariko, ingaruka kuri macula degeneration irahambaye kuruta iya lutein.

9. Kunoza ibitotsi

Kuzuza NMN birashobora kongera urwego rwa NAD + mumubiri, kandi NAD + nayo ifitanye isano rya hafi nisaha yibinyabuzima. Imikoranire hagati ya NAD + nisaha yibinyabuzima igaragarira muburyo metabolism ya NAD + igengwa nisaha yibinyabuzima, nayo ikagira ingaruka kumasaha yibinyabuzima.

NMN ikoreshwa cyane mubiribwa byubuzima kandi ifite ingaruka zo kurwanya gusaza.

β-Nicotinamide mononucleotide niyo ibanziriza NAD +, cofactor ya proteine ​​ndende mu mubiri w'umuntu. NAD + ni coenzyme ikomeye muri cycle ya tricarboxylic, iteza imbere metabolisme yisukari, ibinure, na aside amine, no kugira uruhare mu guhuza ingufu; NAD + niyo substrate yonyine ya coenzyme Nkoresha enzymes (substrate yonyine ya enzyme yo gusana ADN ya PARP, hamwe na substrate yonyine ya proteine ​​yo kuramba Sirtuins Substrate, substrate yonyine ya cyclicale ADP-ribose synthase CD38 / 157). NAD + igira uruhare mubice byose bya metabolism yabantu kandi ni coenzyme yingenzi. Hatari NAD +, metabolism ntabwo izakora. Abantu bageze mu zabukuru babura NAD +, bityo ibibazo bitandukanye bikomeye kandi bito bivuka. Wongeyeho NAD + yinyongera, urashobora kurwanya byimazeyo gusaza.