Ibisobanuro bya Silymarin

Silymarin nuruvange rwa flavonolignan rwakuwe mu ikoti ryimbuto yimbuto ya silymarin yimbuto ya Asteraceae. Ibi bintu ntibishobora gushonga mumazi, bigashonga muri acetone, Ethyl acetate, methanol na Ethanol, kandi bigashonga gato muri chloroform.

Ibigize byingenzi birimo silybin, isosilybin, silybinin na silymarin. Ibyingenzi byingenzi muri silymarin ni silybin, bingana na 50% kugeza 70% byamafaranga yose ya silymarine kandi nikintu gikora cyane kandi cyiza muri silymarine.

Silymarin ntabwo ari imbuto. Ni icyatsi cya Asteraceae. Imbuto zimbuto zikoreshwa nkumuti. Ntabwo ari imbuto ubwayo, ariko imbuto zayo zirashobora gukoreshwa mu kurinda umwijima.

Silymarin ibanza kurinda no guhagarika umwijima w'umwijima w'umwijima, ushobora kunoza imikorere yumwijima kandi bigatanga ingaruka zo kugabanya alanine na aspartate aminotransferase. Icya kabiri, ntabwo byoroshye kwisubiraho nyuma yo kugabanya transaminase, bityo silymarin ikoreshwa cyane cyane kubarwayi bafite alanine nyinshi hamwe na aminotransferase ya aspartate kandi irashobora gukoreshwa mugihe gito mugihe cyangiritse umwijima.

Silymarin ikoreshwa cyane mu miti, ibikomoka ku buzima, ibiryo, amavuta yo kwisiga n'ibindi bicuruzwa. Irashobora kandi gukoreshwa mubworozi nk'inyongeramusaruro.

Ni izihe nyungu za silymarin?

Kurinda umwijima

Silymarin igira ingaruka zo kurinda umwijima kandi irashobora kurinda selile umwijima ibintu bifite ubumara, cyane cyane inzoga n’ibyangiza ibidukikije (imiti yica udukoko, ibyuma biremereye, nibindi) byinjira kandi byangiza umwijima. Silymarin irashobora guhagarika ibikorwa bya synthase ya aside irike hamwe na synthase ya triglyceride mungirangingo zumwijima, bityo bikagabanya amavuta yumwijima, kugabanya umutwaro wumwijima, no kwirinda kwangirika kwumwijima. Izi ngaruka zigira ingaruka zimwe zo kuvura indwara nkindwara yumwijima yinzoga nindwara zumwijima zidafite inzoga.

Imikorere ya Antioxydeant

Silymarin ifite imikorere ikomeye ya antioxydeant, ishobora gukuraho radicals yubusa, ikarinda lipide peroxidisation iterwa na stress ya okiside, kandi ikagira ingaruka zo kwangiza anti-okiside. Irashobora kurinda selile umwijima kwangirika kwubusa, kandi antioxydeant irwanya vitamine E.

Kurwanya inflammatory

Silymarin irashobora guhagarika umusaruro wumuhuza utera nka interleukin-1β, bityo bikagabanya igisubizo cyumwijima. Ifite ingaruka zigabanya ibimenyetso nko gutukura umwijima, kubyimba, no kubabara biterwa na hepatite ikaze cyangwa idakira.

Teza imbere intungamubiri za poroteyine

Silymarin irashobora guteza imbere intungamubiri za poroteyine no kwihutisha gukora ibicuruzwa bishya, bifasha kwihutisha gukora ingirabuzimafatizo nshya cyangwa gusana ingirabuzimafatizo zangiritse.

Guteza imbere ururenda

Silymarin irashobora gutuma irekurwa rya cholecystokinine kandi ikongera ururenda, kandi ikagira ingaruka zimwe na zimwe zo kuvura indwara zifata igifu nka jalestice ya cholestique.

Indwara irwanya umutima

Ubushakashatsi bwerekanye ko silymarin ishobora kongera ubushobozi bwo kurwanya LDL (lipoprotein nkeya), igira ingaruka runaka mukurinda no kuvura indwara zifata umutima.

Nigute silymarin irinda umwijima?

Silymarin irashobora kubona radicals yubuntu, ikabuza inzira yindwara ya lipide peroxidisation, igahindura metabolisme ya lipide mungirangingo zumwijima zangiritse, hanyuma ikagira uruhare rwa antioxydeant. Ikuraho ogisijeni yubusa, igabanya urwego rwo gutwika ingirangingo z'umwijima, igabanya cytotoxicity, bityo ikuraho umwijima.

Irinda gutakaza ibice bigize selile yashonze, irinda sisitemu ya enzyme yingirabuzimafatizo yumwijima, ikomeza ubusugire bwingirangingo zumwijima, kandi ikarinda uburozi kwinjira no kwangiza umwijima. Silymarin irashobora guteza imbere kugarura ultrastructure selile yumwijima, guteza imbere kugabana no gukura kwingirangingo zisanzwe zumwijima, kandi bikongerera ubushobozi ingirabuzimafatizo zumwijima guhuza RNA na proteyine, bityo bikazamura ubushobozi bwo gusana no kuvugurura ingirabuzimafatizo zumwijima.

Yongera ubushobozi bwa sisitemu ya reticuloendothelial kugirango itange macrophage, ishimangira ibikorwa bya macrophage, yihutisha kwandura virusi, bityo itezimbere imikorere yumwijima. Irashobora guhagarika imikorere ya selile stellate selile na cytokine zitandukanye kandi ikirinda kubaho fibrosis yumwijima.

Ese koko Silymarin ni Antioxidant?

Silymarin ni uruganda rusanzwe rufite antioxydeant mu ngirangingo zuruhu. Flavonoide na glycoside ya flavonoide nibyo bintu nyamukuru bigize silymarine, kandi ubushakashatsi bwerekanye ko ibyo bice byombi bishobora kugabanya umusaruro wa hydrogène peroxide muri keratinocytes kandi bikagabanya urupfu rwa hydrogène peroxide.

Mu bushakashatsi bumwe, silymarin yasanze igira ingaruka ziterwa na antioxydeant ya fibroblast isanzwe yuruhu rwabantu. Igishimishije, urugero rwo hasi rwa silymarin, 0.0001%, rwagize ingaruka zikomeye za antioxydeant muri hydrogène peroxide iterwa na okiside itera imbaraga. Uyu mwanzuro ni ingenzi cyane kuko ushimangira akamaro k’ubushakashatsi bwibanze kugirango uhitemo antioxydeant ikwiye kugirango urinde uruhu guhangayika. Igeragezwa ryibanze ryubushobozi bwa antioxydeant ntirigarukira gusa kuri silymarine, ahubwo rigomba no kwaguka no ku zindi antioxydants, zishobora gufasha guhitamo uburyo bwo guhitamo ibicuruzwa biva mu mahanga kugira ngo byinjizwe mu bikoresho byita ku ruhu kugira ngo bikoreshe abarwayi.

Silymarin yerekanye imiterere ya Photoprotective muburyo bwuruhu rwinyamaswa. Muburyo bwimbeba, kuvura silymarin byagabanije umusaruro wa UVB uterwa na hydrogène hydrogène peroxide yakozwe muri epidermis na dermis zuruhu. Byongeye kandi, silymarin irinda izuba ryatewe na UVB. Byongeye kandi, silymarin ifite imiterere ya Photoprotective muruhu rwumuntu muguhindura inzira ya ogisijeni yubusa yubusa kandi ikabuza UVB iterwa na keratinocyte apoptose ikoresheje antioxydeant.

Silymarin yerekanye anti-fibrotic mumiterere ya vitro. Silymarin ivura fibroblast yibanze ya dermal yatumye habaho kugabanuka kwubwoko bwa I collagen synthesis. Uku kugabanuka kwa kolagen biterwa no kubuza inzira ya TGF-β unyuze kuri Smad2 / 3.

Ni iki silymarin ishobora gukoreshwa?

Urwego rwubuvuzi

Silymarin ifite ingaruka zo kurwanya stress ya okiside, iteza intungamubiri za poroteyine no kuvugurura ingirabuzimafatizo. Nubuvuzi gakondo bwo kuvura ubwoko butandukanye bwindwara zumwijima nuburozi bwibihumyo. Hamwe n’ubushakashatsi bwimbitse, bugira ingaruka zo kugenzura ingirabuzimafatizo, gutera selile apoptose, kubuza neovascularization, anti-inflammatory, lipid-igenga na neuroprotective.

Ibicuruzwa byita ku buzima

Gukoresha silymarin mubicuruzwa byubuzima ni nkibikoresho byo kurinda umwijima. Irashobora gufasha neza umwijima kurandura uburozi, kugabanya cholesterol na triglyceride ikabije mu mubiri wumuntu, no gusohora uburozi buva "mumyanda isanzwe" nyuma yo gutunganywa numwijima, bifite inyungu zo kweza amaraso, kwangiza no kwiza.

Umurima w'ibiribwa

Silymarin irashobora gukoreshwa nk'inyongeramusaruro kandi ikongerwamo ibiryo kugirango ubuzima bwibiryo bwiyongere. Kurugero, irashobora gukoreshwa mugukora no gutunganya ibiryo bikora, ibinyobwa nibicuruzwa byubuzima.

Umwanya wo kwisiga

Silymarin irashobora kandi gukoreshwa mubikorwa byo kwisiga kuko ifite ingaruka zimwe na zimwe za antioxydeant kandi irashobora gukuraho neza radicals yubusa ikabije mumubiri kugirango yirinde kwangirika kwingirabuzimafatizo mumubiri.