01
vitamine E TPGS D-α-Tocopherol polyethylene glycol 1000 isimburana
Vitamine E TPGS ni iki?
Vitamine E polyethylene glycol succinate (TPGS mu magambo ahinnye) ni amazi akuramo amazi akomoka kuri vitamine E, ikorwa nigisubizo hagati yitsinda rya carboxyl ya vitamine E hamwe na hydroxyl ya polyethylene glycol. Kubera ko irimo itsinda rya lipofilique ya vitamine E hamwe n’urunigi rurerure rwa hydrophilique ya polyethylene glycol, ifite imiterere myiza ya surfactant hamwe n’amazi meza, kandi irashobora kongera cyane kwinjiza imiti idashonga neza mu nzira ya gastrointestinal. Kunoza bioavailability.
Vitamine E polyethylene glycol succinc ubu ikoreshwa cyane mubushakashatsi bwakozwe nka solubilizer, kongera imbaraga, emulisiferi, plasitike, hamwe nogutwara sisitemu yo gutanga imiti idahwitse cyangwa ibinure byamavuta, nko gutatanya gukomeye, abatwara imiyoborere ya ocular, abatwara imiyoborere idasanzwe, nibindi, ubushakashatsi bwakozwe bwerekanye ko imiti myinshi ya TPS, yongeyeho ko ubushakashatsi bwakozwe na farumasi nyinshi, nkukwongerera imbaraga hamwe na multidrug resistance reaction agent. TPGS irashobora kandi gukoreshwa muri prodrugs, micelles, lipide, nibindi. Plasima na TPGS-copolymer itwara bikoreshwa mugutezimbere, gukomera no gutuza kwimyiteguro, bityo bikagerwaho kurekurwa buhoro, kugenzurwa ningaruka zigamije, no guteza imbere ibiyobyabwenge.
Imikorere no kuyishyira mu bikorwa
TPGS (D-α-tocopherol polyethylene glycol 1000 succinate) ni ibintu byinshi bigamije gutanga ibiyobyabwenge, ahanini bikoreshwa mugutezimbere, bioavailability hamwe nibihamye byibiyobyabwenge. Muri sisitemu yo gutanga ibiyobyabwenge, TPGS ikora muburyo bukurikira:
1. Kongera ibiyobyabwenge:TPGS ifite amazi meza kandi irashobora gukora inganda zifite imiti ya hydrophobique, bityo igateza imbere imiti mumazi. Ibi bituma imiti yoroha cyane mumubiri, igahindura bioavailable yibiyobyabwenge.
2. Kurinda ibiyobyabwenge kwangirika kwimisemburo:TPGS irashobora gupfunyika hejuru yibiyobyabwenge kugirango ikore firime ikingira kugirango hirindwe kwangirika kwimiti yibiyobyabwenge mumubiri. Ifasha kongera igihe cyo gukwirakwiza enterohepatike yibiyobyabwenge no kunoza imikorere yibiyobyabwenge.
3. Guhindura igipimo cyo kurekura ibiyobyabwenge:Kurekura buhoro cyangwa kurekura byihuse birashobora kugerwaho muguhindura umubare wa TPGS.
4. Kunoza umutekano wibiyobyabwenge:TPGS igira ingaruka za antioxydeant kandi irashobora kurinda ibiyobyabwenge kwangirika kwa okiside. Byongeye kandi, TPGS irashobora kandi kubuza imikoranire hagati yibiyobyabwenge nibindi bintu no kugabanya kubora no kwangirika kwibiyobyabwenge.
5. Kunoza imiti ya farumasi:TPGS irashobora kunoza uburyo bwo gufata mu kanwa imiti no kugabanya ihindagurika rya plasma yibiyobyabwenge, bityo bikazamura imiti ya farumasi.
Vitamine E TPGS nayo ikoreshwa nkisoko ikomeye ya vitamine E karemano yo kuvura no kurya.
TPGS ni vitamine E ibora mu mazi, itandukanye na vitamine E ikuramo ibinure kandi ikinjira mu mubiri binyuze mu buryo butandukanye rwose. Vitamine E ikuramo ibinure ikenera kwishingikiriza kuri cholate mu mara kugirango irangize kwinjiza kuva mu mara kugeza mu ngirabuzimafatizo ntoya, mu gihe TPGS ishobora gutwara vitamine E mu ngirabuzimafatizo ntoya yonyine itabigizemo uruhare.
